“Middlesex” is a novel by Jeffrey Eugenides. It follows the multigenerational story of the Stephanides family, exploring themes of identity, gender, and the American experience. The protagonist, Calliope Stephanides, later known as Cal, embarks on a journey to understand her/his identity, leading to the revelation of a family secret and a unique genetic history. The novel spans from a village in Asia Minor to Detroit, providing a rich exploration of cultural and historical contexts.